Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients

@article{Iijima2002TumorSP,
  title={Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients},
  author={Miho Iijima and Peter N. Devreotes},
  journal={Cell},
  year={2002},
  volume={109},
  pages={599-610}
}
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains specific for PI(3,4,5)P3 at sites on the membrane where rearrangements of the cytoskeleton and pseudopod extension occur. Disruption of the PI 3-phosphatase, PTEN, in Dictyostelium discoideum dramatically prolonged and broadened the PH domain relocation and actin polymerization responses, causing the cells lacking PTEN to follow a circuitous route toward the attractant… CONTINUE READING
Highly Influential
This paper has highly influenced 32 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 311 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Chemokines in pathology and medicine . J . translocation of CRAC to membranes

  • T. Maehama, J. E. Dixon
  • J . Cell Biol . Intern . Med .
  • 2001

PTEN and myotu

  • T. Maehama, G. S. Taylor, J. E. Dixon
  • 2001
1 Excerpt

Central role for G protein - coupled phosphoinositideamount of [ 32 P ] cAMP synthesized in 1 min was measured as de3 - kinase  in inflammation

  • P. Devreotes
  • Science
  • 2000

DAF - 18 , acts in the insulin receptorlike metabolic signaling path

  • M. P. Wymann, S. Sozzani, F. Altruda, A. Mantovani, E. Hirsch
  • Mol . Cell
  • 2000

Similar Papers

Loading similar papers…