Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients

  title={Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients},
  author={Miho Iijima and Peter N. Devreotes},
Shallow gradients of chemoattractants, sensed by G protein-linked signaling pathways, elicit localized binding of PH domains specific for PI(3,4,5)P3 at sites on the membrane where rearrangements of the cytoskeleton and pseudopod extension occur. Disruption of the PI 3-phosphatase, PTEN, in Dictyostelium discoideum dramatically prolonged and broadened the PH domain relocation and actin polymerization responses, causing the cells lacking PTEN to follow a circuitous route toward the attractant… CONTINUE READING
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