Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate

@inproceedings{Agarwal2012TumorSG,
  title={Tumor Suppressor Gene p16/INK4A/CDKN2A and Its Role in Cell Cycle Exit, Differentiation, and Determination of Cell Fate},
  author={Payal Agarwal and Farruk M. Lutful Kabir and Patricia Deinnocentes and Richard C. Bird},
  year={2012}
}
Tumor suppressor genes and oncogenes are important regulatory genes which encode proteins regulating transitions in and out of the cell cycle and which also have a role in the gateway to terminal differentiation (Tripathy & Benz, 1992). Defects in tumor suppressor genes and oncogenes result in uncontrolled cell division, which leads to cancer (Tripathy & Benz, 1992). Oncogenes are mutated proto-oncogenes that have a role in malignancy of tumors and most frequently regulate cell cycle re-entry… CONTINUE READING

Figures from this paper.

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

IMUNOHISTOKIMIA PADA KONDILOMATA AKUMINATA

Meidyta Sinantryana Widyaswari, Hans Lumintang, Troef Soemarno
  • 2019
VIEW 1 EXCERPT

References

Publications referenced by this paper.
SHOWING 1-10 OF 219 REFERENCES

Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.

  • Biochemical and biophysical research communications
  • 2010
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

INK4a/ARF: a multifunctional tumor suppressor locus.

  • Mutation research
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Complex structure and regulation of the P16 (MTS1) locus.

  • Cancer research
  • 1995
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL