Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA Methyltransferase

@inproceedings{BenbrahimTallaa2007TumorSG,
  title={Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA Methyltransferase},
  author={Lamia Benbrahim-Tallaa and Robert A. Waterland and Anna L. Dill and Mukta M. Webber and Michael P. Waalkes},
  booktitle={Environmental health perspectives},
  year={2007}
}
BACKGROUND Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation. OBJECTIVES During cadmium-induced malignant transformation, an unusual pattern of genomic hypermethylation occurred that we studied to provide insight into the roles of specific DNMTs in oncogenesis… CONTINUE READING
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