Tumor Size-Dependent Anticancer Efficacy of Chlorin Derivatives for Photodynamic Therapy

@inproceedings{Chang2018TumorSA,
  title={Tumor Size-Dependent Anticancer Efficacy of Chlorin Derivatives for Photodynamic Therapy},
  author={Ji-Eun Chang and Yang Liu and Tae Heon Lee and Woo Kyoung Lee and Il Joong Yoon and Kwhanmien Kim},
  booktitle={International journal of molecular sciences},
  year={2018}
}
Photodynamic therapy (PDT) with a suitable photosensitizer molecule is a promising anticancer treatment. We evaluated two chlorin molecules as potential photosensitizers, methyl pyropheophorbide a (MPPa) and N-methoxyl purpurinimide (NMPi), against A549 human lung adenocarcinoma cells in vitro as well as in A549 tumor-bearing mice in vivo. Cell viability, microscopy, and fluorescence-activated cell sorting (FACS) analyses were performed for the in vitro studies. MPPa and NMPi showed high… CONTINUE READING

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