Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*

@article{Lin2004TumorNF,
  title={Tumor Necrosis Factor-induced Nonapoptotic Cell Death Requires Receptor-interacting Protein-mediated Cellular Reactive Oxygen Species Accumulation*},
  author={Yong Lin and S. Choksi and Han-Ming Shen and Qing-feng Yang and G. M. Hur and Y. Kim and J. Tran and S. Nedospasov and Z. Liu},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={10822 - 10828}
}
  • Yong Lin, S. Choksi, +6 authors Z. Liu
  • Published 2004
  • Biology, Medicine
  • Journal of Biological Chemistry
  • The mechanism of tumor necrosis factor (TNF)-induced nonapoptotic cell death is largely unknown, although the mechanism of TNF-induced apoptosis has been studied extensively. In wild-type mouse embryonic fibroblast cells under a caspase-inhibited condition, TNF effectively induced cell death that morphologically resembled necrosis. In this study, we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor (TNFR) I mediates TNF-induced necrotic cell… CONTINUE READING
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