Tumor Necrosis Factor and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier

@inproceedings{Bauer2007TumorNF,
  title={Tumor Necrosis Factor and Endothelin-1 Increase P-Glycoprotein Expression and Transport Activity at the Blood-Brain Barrier},
  author={Bjoern Bauer and Anika M. S. Hartz and David Scott Miller},
  year={2007}
}
The ATP-driven drug efflux pump, P-glycoprotein, is a critical and selective element of the blood-brain barrier and a primary impediment to pharmacotherapy of central nervous system (CNS) disorders. Thus, an understanding of how P-glycoprotein function is regulated has the potential to improve CNS therapy. We recently demonstrated rapid (minutes) and reversible inactivation of P-glycoprotein in rat brain capillaries signaled through tumor necrosis factor(TNF) and endothelin-1 (ET1), components… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Molecular mechanism of TNF signaling and beyond

  • ZG Liu
  • Cell Res
  • 2005
1 Excerpt

Similar Papers

Loading similar papers…