Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-κB Activation*

@article{FotinMleczek2004TumorNF,
  title={Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-$\kappa$B Activation*},
  author={M. Fotin‐Mleczek and F. Henkler and A. Hausser and Heike Glauner and D. Samel and A. Graness and P. Scheurich and D. Mauri and H. Wajant},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={677 - 685}
}
To investigate CD40 signaling complex formation in living cells, we used green fluorescent protein (GFP)-tagged CD40 signaling intermediates and confocal life imaging. The majority of cytoplasmic TRAF2-GFP and, to a lesser extent, TRAF3-GFP, but not TRAF1-GFP or TRAF4-GFP, translocated into CD40 signaling complexes within a few minutes after CD40 triggering with the CD40 ligand. The inhibitor of apoptosis proteins cIAP1 and cIAP2 were also recruited by TRAF2 to sites of CD40 signaling. An… Expand

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