Tumor Necrosis Factor Receptor Pre-Ligand Assembly Domain is an Important Therapeutic Target in Inflammatory Arthritis

Abstract

Tumor necrosis factor (TNF)-α is an important proinflammatory cytokine and plays a crucial role in pathogenesis of inflammatory arthritis, such as rheumatoid and septic arthritis. TNFα exerts its effect by binding to the extracellular domain of TNF receptor (TNFR) 1 and 2. The amino-terminal portion of the TNFR extracellular domain, known as cysteine rich… (More)
DOI: 10.2165/00063030-200721010-00004

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@article{Deng2007TumorNF, title={Tumor Necrosis Factor Receptor Pre-Ligand Assembly Domain is an Important Therapeutic Target in Inflammatory Arthritis}, author={Dr Guo-Min Deng}, journal={BioDrugs}, year={2007}, volume={21}, pages={23-29} }