Tumor Necrosis Factor-α-Induced Ototoxicity in Mouse Cochlear Organotypic Culture

@inproceedings{Wu2015TumorNF,
  title={Tumor Necrosis Factor-α-Induced Ototoxicity in Mouse Cochlear Organotypic Culture},
  author={Qian Wu and Guo-peng Wang and Jing Xie and Jing-ying Guo and Shu-sheng Gong and Jonathan Isamu Matsui},
  booktitle={PloS one},
  year={2015}
}
Tumor necrosis factor (TNF)-α is a cytokine involved in acute inflammatory phase reactions, and is the primary upstream mediator in the cochlear inflammatory response. Treatment of the organ of Corti with TNF-α can induce hair cell damage. However, the resulting morphological changes have not been systematically examined. In the present study, cochlear organotypic cultures from neonatal mice were treated with various concentrations and durations of TNF-α to induce inflammatory responses… CONTINUE READING
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