Tumor Necrosis Factor-α Increases Lactoferrin Transcytosis Through the Blood-Brain Barrier

@inproceedings{Fillebeen2002TumorNF,
  title={Tumor Necrosis Factor-α Increases Lactoferrin Transcytosis Through the Blood-Brain Barrier},
  author={Carine Fillebeen and B{\'e}n{\'e}dicte Dehouck and Monique Benaissa and Isabelle Dhennin‐Duthille and Rom{\'e}o Cecchelli and Annick Pierce},
  year={2002}
}
  • Carine Fillebeen, Bénédicte Dehouck, +3 authors Annick Pierce
  • Published 2002
  • Biology
  • Abstract : Lactoferrin (Lf) is an iron-binding protein involved in host defense against infection and severe inflammation, which accumulates in the brain during neurodegenerative disorders. Prior to determining Lf function in pathological brain tissues, we investigated its transport through the blood-brain barrier (BBB) in inflammatory conditions. For this purpose, we used a reconstituted BBB model consisting of the coculture of bovine brain capillary endothelial cells (BBCECs) and astrocytes… CONTINUE READING

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