Tumor Necrosis Factor-α +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease

@article{Kkaycan2002TumorNF,
  title={Tumor Necrosis Factor-α +489G/A gene polymorphism is associated with chronic obstructive pulmonary disease},
  author={Mehmet K{\"u}ç{\"u}kaycan and Michiel V van Krugten and H. P. G. Pennings and Thomas W. J. Huizinga and Wim A. Buurman and Mieke A. Dentener and Emiel F. M. Wouters},
  journal={Respiratory Research},
  year={2002},
  volume={3},
  pages={29 - 29}
}
BACKGROUND Chronic obstructive pulmonary disease (COPD) is characterized by a chronic inflammatory process, in which the pro-inflammatory cytokine Tumor Necrosis Factor (TNF)-alpha is considered to play a role. In the present study the putative involvement of TNF-alpha gene polymorphisms in pathogenesis of COPD was studied by analysis of four TNF-alpha gene… CONTINUE READING