Tumor Necrosis Factor (TNF- ) Activates Jak1/Stat3-Stat5B Signaling through TNFR-1 in Human B Cells


The biological actions of tumor necrosis factor (TNF) are mediated by two cell surface receptors, TNFR-1 and TNFR-2. These receptors do not display protein tyrosine kinase activity. Nevertheless, an early TNFinduced activation of specific tyrosine kinases has been reported as an important cue to the cellular response to this cytokine. Here we present… (More)


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