Tumor Necrosis Factor&agr; Modulates Matrix Production and Catabolism in Nucleus Pulposus Tissue

@article{Sguin2005TumorNF,
  title={Tumor Necrosis Factor&agr; Modulates Matrix Production and Catabolism in Nucleus Pulposus Tissue},
  author={C. S{\'e}guin and R. Pilliar and P. Roughley and R. Kandel},
  journal={Spine},
  year={2005},
  volume={30},
  pages={1940-1948}
}
Study Design. This study examines changes in the production of extracellular matrix molecules as well as the induction of tissue degradation in in vitro formed nucleus pulposus (NP) tissues following incubation with tumor necrosis factor (TNF)&agr;. Objective. To characterize the response of NP cells to TNF-&agr;, a proinflammatory cytokine present in herniated NP tissues. Summary of Background Data. TNF-&agr; is a proinflammatory cytokine expressed by NP cells of degenerate intervertebral… Expand
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