Tumor Microenvironment and Myeloid-Derived Suppressor Cells

  title={Tumor Microenvironment and Myeloid-Derived Suppressor Cells},
  author={Viktor Umansky and Alexandra Sevko},
  journal={Cancer Microenvironment},
Tumor progression has been demonstrated to be supported by chronic inflammatory conditions developed in the tumor microenvironment and characterized by the long-term secretion of various inflammatory soluble factors (including cytokines, chemokines, growth factors, reactive oxygen and nitrogen species, prostaglandins etc.) and strong leukocyte infiltration. Among leukocytes infiltrating tumors, myeloid-derived suppressor cells (MDSCs) represent one of the most important players mediating… CONTINUE READING


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