Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.

@article{JunckerJensen2013TumorMA,
  title={Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination.},
  author={Anna Juncker-Jensen and Elena I. Deryugina and Ivo Rimann and Ewa Zając and Tatyana A. Kupriyanova and Lars Henning Engelholm and James P. Quigley},
  journal={Cancer research},
  year={2013},
  volume={73 14},
  pages={
          4196-211
        }
}
Intravasation, the active entry of primary tumor cells into the vasculature, remains the least studied step in the metastatic cascade. Protease-mediated escape and stromal invasion of tumor cells represent widely accepted processes leading up to the intravasation step. However, molecular factors that contribute directly to tumor cell vascular penetration have not been identified. In this study, the in vivo role of the collagenolytic protease, MMP-1, in cancer cell intravasation and metastasis… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Identification of a gene signature for rapid screening of oral squamous cell carcinoma.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2012

Matrix metalloprotease-1a promotes tumorigenesis and metastasis.

  • The Journal of biological chemistry
  • 2012
VIEW 1 EXCERPT

Matrix metalloproteinases and their clinical relevance in urinary bladder cancer

T Szarvas, F vomDorp, RubbenH Ergun S
  • Nat Rev Urol
  • 2011