Tumor Lesion Detection: When Is Integrated Positron Emission Tomography/Computed Tomography More Accurate Than Side-by-Side Interpretation of Positron Emission Tomography and Computed Tomography?

@article{Metser2005TumorLD,
  title={Tumor Lesion Detection: When Is Integrated Positron Emission Tomography/Computed Tomography More Accurate Than Side-by-Side Interpretation of Positron Emission Tomography and Computed Tomography?},
  author={Ur Metser and Orit Golan and Charles Levine and Einat Even-Sapir},
  journal={Journal of Computer Assisted Tomography},
  year={2005},
  volume={29},
  pages={554-559}
}
Objectives: To determine if there is added value to oncology studies performed with a dedicated in-line positron emission tomography (PET)/computed tomography (CT) scanner as compared with PET read side by side with diagnostic CT (DCT). Methods: Forty-one consecutive oncology patients referred for PET/CT who had contemporary DCT scans for review were enrolled. Body regions assessed on a DCT scan were assessed on PET/CT and by side-by-side reading of PET and DCT (SBS PET/DCT). Lesions identified… 

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References

SHOWING 1-10 OF 12 REFERENCES

Side-by-side reading of PET and CT scans in oncology: which patients might profit from integrated PET/CT?

It is concluded that side-by-side viewing of PET and CT scans is essential, as in 42.4% of all cases, combined viewing was important for a correct diagnosis in the series.

Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET.

  • G. AntochN. Saoudi L. Freudenberg
  • Medicine, Physics
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
Tumor staging with PET/CT is significantly more accurate than CT alone, PET alone, and side-by-side PET + CT and this diagnostic advantage translates into treatment plan changes in a substantial number of patients.

PET/CT in diagnostic oncology.

  • C. MessaV. Bettinardi F. Fazio
  • Medicine, Physics
    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
  • 2004
advantages of PET/CT over PET that may influence the clinical routine, have been identified as a) the shorter image acquisition time with benefit on patients throughput and on patient compliance, b) the better accuracy in anatomically localizing focal areas of abnormal tracer uptake and defining tumor extent and c) the possibility to stage a disease in 1 single step.

Value of integrated PET/CT for lesion localisation in cancer patients: a comparative study

In cancer patients, PET/CT shows higher diagnostic accuracy for lesion localisation than PET plus morphological imaging studies performed independently, and this result does not seem to be affected by the type of tracer used.

Integrated FDG PET/CT in patients with persistent ovarian cancer: correlation with histologic findings.

Imaging findings were compared with results of histologic examination after surgical second-look to determine the diagnostic accuracy of PET/CT in the evaluation of disease status, and integratedPET/CT depicts persistent ovarian carcinoma with a high positive predictive value.

PET-CT in recurrent ovarian cancer: initial observations.

Combined functional-anatomic imaging with fused PET and computed tomographic (CT) scans is feasible and may improve disease detection by increasing radiologic sensitivity and specificity and increase diagnostic confidence at CT.

Malignant involvement of the spine: assessment by 18F-FDG PET/CT.

F- FDG PET/CT has better specificity for detection of malignant involvement of the spine than does (18)F-FDG PET, which allows for precise localization of lesions and identifies accompanying soft-tissue involvement, which is of potential neurologic significance.

Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection.

PET/CT is an accurate technique in the detection of pelvic recurrence after surgical removal of rectal cancer with sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 96%, 88%, and 100%, respectively.

Why nearly all PET of abdominal and pelvic cancers will be performed as PET/CT.

  • R. Wahl
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2004
UNLABELLED Clinical experience at Johns Hopkins and published literature regarding PET/CT applications in the abdomen and pelvis are reviewed, and the strengths and limitations of this evolving

Oncological applications of FDG PET imaging.

  • D. Delbeke
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1999
This article focuses on applications of FDG PET imaging for breast cancer, pancreatic cancer, hepatocellular carcinoma and other body tumors.