Tumor Lesion Detection: When Is Integrated Positron Emission Tomography/Computed Tomography More Accurate Than Side-by-Side Interpretation of Positron Emission Tomography and Computed Tomography?

  title={Tumor Lesion Detection: When Is Integrated Positron Emission Tomography/Computed Tomography More Accurate Than Side-by-Side Interpretation of Positron Emission Tomography and Computed Tomography?},
  author={Ur Metser and Orit Golan and Charles Levine and Einat Even-Sapir},
  journal={Journal of Computer Assisted Tomography},
Objectives: To determine if there is added value to oncology studies performed with a dedicated in-line positron emission tomography (PET)/computed tomography (CT) scanner as compared with PET read side by side with diagnostic CT (DCT). Methods: Forty-one consecutive oncology patients referred for PET/CT who had contemporary DCT scans for review were enrolled. Body regions assessed on a DCT scan were assessed on PET/CT and by side-by-side reading of PET and DCT (SBS PET/DCT). Lesions identified… 

Diagnostic evaluation of separately acquired positron emission tomography and computerized tomography images by nuclear medicine physicians and radiologists in cancer patients

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Hybrid imaging (SPECT/CT and PET/CT)--improving the diagnostic accuracy of functional/metabolic and anatomic imaging.

Improved diagnostic accuracy is reflected by improving image quality of SPECT and PET, detection of more clinically relevant lesions, better localization of disease and differentiation between physiologic and pathologic uptake, characterization of disease by its functional and morphologic appearance before and after therapy and accurate delineation of disease, optimizing biopsy and therapy planning.

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A patient with a germ cell tumour of the testis, who underwent a PET/CT scan to detect the site of relapse with a view to surgical removal mislocalised the tumour site to be within the T2 vertebral body, which was confirmed at surgery.

Comparison of MRI Sequences in Whole-Body PET/MRI for Staging of Patients With High-Risk Prostate Cancer.

Metastases from prostate cancer are best detected at DWI or gadolinium-enhanced T1-weighted VIBE sequences, which is the most time-efficient sequence with the highest lesion detection rate and conspicuity.

Inter-observer variations in FDG-PET interpretation for cancer screening.

The interpretation of FDG-PET is adequately reproducible, while that of 'Normal' subjects is less reproducible; improvement of inter-observer variability in assessing physiological FDG uptakes requires universal reporting criteria in FDG

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F-FDG PET/CT improves the performance of (18)F- FDG PET alone in discriminating benign from malignant adrenal lesions in oncology patients.

The clinical impact of [18F]FDG PET/CT for the management of recurrent endometrial cancer: correlation with clinical and histological findings

Integrated PET/CT appears to be highly sensitive, specific, and accurate as a post-therapy surveillance modality for endometrial cancer in well-selected patients and might be used to improve patient surveillance and prognosis.



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Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET.

  • G. AntochN. Saoudi L. Freudenberg
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    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2004
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PET/CT in diagnostic oncology.

  • C. MessaV. Bettinardi F. Fazio
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    The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...
  • 2004
advantages of PET/CT over PET that may influence the clinical routine, have been identified as a) the shorter image acquisition time with benefit on patients throughput and on patient compliance, b) the better accuracy in anatomically localizing focal areas of abnormal tracer uptake and defining tumor extent and c) the possibility to stage a disease in 1 single step.

Value of integrated PET/CT for lesion localisation in cancer patients: a comparative study

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Integrated FDG PET/CT in patients with persistent ovarian cancer: correlation with histologic findings.

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PET-CT in recurrent ovarian cancer: initial observations.

Combined functional-anatomic imaging with fused PET and computed tomographic (CT) scans is feasible and may improve disease detection by increasing radiologic sensitivity and specificity and increase diagnostic confidence at CT.

Malignant involvement of the spine: assessment by 18F-FDG PET/CT.

F- FDG PET/CT has better specificity for detection of malignant involvement of the spine than does (18)F-FDG PET, which allows for precise localization of lesions and identifies accompanying soft-tissue involvement, which is of potential neurologic significance.

Detection of recurrence in patients with rectal cancer: PET/CT after abdominoperineal or anterior resection.

PET/CT is an accurate technique in the detection of pelvic recurrence after surgical removal of rectal cancer with sensitivity, specificity, positive predictive value, and negative predictive value of 100%, 96%, 88%, and 100%, respectively.

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  • R. Wahl
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    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 2004
UNLABELLED Clinical experience at Johns Hopkins and published literature regarding PET/CT applications in the abdomen and pelvis are reviewed, and the strengths and limitations of this evolving

Oncological applications of FDG PET imaging.

  • D. Delbeke
  • Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1999
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