Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules

@inproceedings{Bernard2010TumorGR,
  title={Tumor Growth Rate Determines the Timing of Optimal Chronomodulated Treatment Schedules},
  author={Samuel Bernard and Branka Cajavec Bernard and Francis L{\'e}vi and Hanspeter Herzel},
  booktitle={PLoS Computational Biology},
  year={2010}
}
In host and cancer tissues, drug metabolism and susceptibility to drugs vary in a circadian (24 h) manner. In particular, the efficacy of a cell cycle specific (CCS) cytotoxic agent is affected by the daily modulation of cell cycle activity in the target tissues. Anti-cancer chronotherapy, in which treatments are administered at a particular time each day, aims at exploiting these biological rhythms to reduce toxicity and improve efficacy of the treatment. The circadian status, which is the… CONTINUE READING