Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.

@article{Kalbasi2017TumorDerivedCM,
  title={Tumor-Derived CCL2 Mediates Resistance to Radiotherapy in Pancreatic Ductal Adenocarcinoma.},
  author={Anusha Kalbasi and Chad A. Komar and Graham M. Tooker and Mingen Liu and Jae Seop Lee and Whitney L. Gladney and Edgar Ben-Josef and Gregory L Beatty},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 1},
  pages={
          137-148
        }
}
  • Anusha Kalbasi, Chad A. Komar, +5 authors Gregory L Beatty
  • Published in
    Clinical cancer research : an…
    2017
  • Biology, Medicine
  • PURPOSE Local tumor growth is a major cause of morbidity and mortality in nearly 30% of patients with pancreatic ductal adenocarcinoma (PDAC). Radiotherapy is commonly used for local disease control in PDAC, but its efficacy is limited. We studied the impact of selectively intervening on radiotherapy-induced inflammation as an approach to overcome resistance to radiotherapy in PDAC. EXPERIMENTAL DESIGN PDAC cell lines derived from primary pancreatic tumors arising spontaneously in KrasLSL… CONTINUE READING

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