Tumor Cell Survival Dependence on the DHX9 DExH-Box Helicase

@inproceedings{Lee2016TumorCS,
  title={Tumor Cell Survival Dependence on the DHX9 DExH-Box Helicase},
  author={Teresa Lee and Maril{\`e}ne Paquet and O Larsson and J. -P. Pelletier},
  booktitle={Oncogene},
  year={2016}
}
The NTP-dependent DExH/D-box helicase DHX9 is a key participant in a number of gene regulatory steps, including transcriptional, translational, and microRNA-mediated control, DNA replication and maintenance of genomic stability. DHX9 has also been implicated in tumor cell maintenance and drug response. Here we report that inhibition of DHX9 expression is lethal to human cancer cell lines and murine Eμ−Myc lymphomas. Using a novel conditional shDHX9 mouse model, we demonstrate that sustained and… CONTINUE READING
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