Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots In Vivo.

@article{Yao2017TumorCN,
  title={Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots In Vivo.},
  author={Chenjie Yao and Yusong Tu and Lin Ding and Chao-Jun Li and Jiao Wang and Haiping Fang and Yanan Huang and Kangkang Zhang and Quan Lu and Minghong Wu and Yanli Wang},
  journal={Bioconjugate chemistry},
  year={2017},
  volume={28 10},
  pages={2608-2619}
}
Specific targeting of tumor tissues is essential for tumor imaging and therapeutics but remains challenging. Here, we report an unprecedented method using synthetic sulfonic-graphene quantum dots (sulfonic-GQDs) to exactly target the cancer cell nuclei in vivo without any bio- ligand modification, with no intervention in cells of normal tissues. The key… CONTINUE READING