Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer.

@article{Niu2016TumorAssociatedMT,
  title={Tumor-Associated Macrophage-Mediated Targeted Therapy of Triple-Negative Breast Cancer.},
  author={Mengmeng Niu and Solange A. Valdes and Youssef W Naguib and Stephen D. Hursting and Zhengrong Cui},
  journal={Molecular pharmaceutics},
  year={2016},
  volume={13 6},
  pages={
          1833-42
        }
}
Triple-negative breast cancer (TNBC) is the most aggressive form of breast cancer. TNBC is often infiltrated with a large number of macrophages, which in turn promote tumor growth and metastasis. In this study, tumor-associated macrophages (TAMs) were exploited as a target to deliver doxorubicin (DOX), a chemotherapeutic agent, to TNBC using nanoparticles surface-functionalized by (i) acid-sensitive sheddable PEGylation and (ii) modifying with mannose (i.e., DOX-AS-M-PLGA-NPs). In mice with… CONTINUE READING
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