Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis

@inproceedings{Shih2006TumorAssociatedMI,
  title={Tumor-Associated Macrophage: Its Role in Cancer Invasion and Metastasis},
  author={Jin-Yuan Shih and Ang Yuan and Jeremy J. W. Chen and Pan-Chyr Yang},
  year={2006}
}
Cancer metastasis is not exclusively regulated by the deregulation of metastasis-promoting or suppressing genes in cancer cells. The interaction between cancer cells and the stromal cells has been shown recently to promote cancer metastasis. The macrophages within the tumor, referring to as tumour-associated macrophages (TAMs), are the pivotal member of stromal cells. TAMs are derived from peripheral blood monocytes recruited into the tumor. Upon activated by cancer cells, the TAMs can release… CONTINUE READING

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