Tumor‐selective Distribution of an Active Metabolite of the 9‐Aminoanthracycline Amrubicin

@inproceedings{Noguchi1998TumorselectiveDO,
  title={Tumor‐selective Distribution of an Active Metabolite of the 9‐Aminoanthracycline Amrubicin},
  author={Toshihiro Noguchi and Shinji Ichii and Shinya Morisada and Takashi Yamaoka and Yoshikazu Yanagi},
  booktitle={Japanese journal of cancer research : Gann},
  year={1998}
}
It has been reported that the 9-aminoanthracycline amrubicin shows good efficacy in human tumor xenograft models. We studied the disposition and metabolism of amrubicin in mice, in comparison with those of doxorubicin. Amrubicinol, a 13-hydroxy metabolite of amrubicin, which is 10 to 100 times more cytotoxic than amrubicin, was detected as a major… CONTINUE READING