Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.

@article{Zavortink2005TumRacGAP50CPA,
  title={Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.},
  author={Michael Zavortink and Nelida Contreras and Tracie M Addy and Amy Bejsovec and Robert E. Saint},
  journal={Journal of cell science},
  year={2005},
  volume={118 Pt 22},
  pages={5381-92}
}
A central question in understanding cytokinesis is how the cleavage plane is positioned. Although the positioning signal is likely to be transmitted via the anaphase microtubule array to the cell cortex, exactly how the microtubule array determines the site of contractile ring formation remains unresolved. By analysing tum/RacGAP50C mutant Drosophila embryos we show that cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase… CONTINUE READING