Tuft-shaped astrocytes in Lewy body disease

  title={Tuft-shaped astrocytes in Lewy body disease},
  author={Nozomi Hishikawa and Yoshio Hashizume and Mari Yoshida and Jun-ichi Niwa and Fumiaki Tanaka and Gen Sobue},
  journal={Acta Neuropathologica},
We investigated the occurrence and distribution of tuft-shaped astrocytes (TuSAs) in 60 brains from patients with Lewy body disease (LBD), which were clinically diagnosed as Parkinson’s disease (PD) or dementia with Lewy bodies (DLB), and 85 brains from control subjects. TuSAs have been documented as a neuropathological hallmark of progressive supranuclear palsy (PSP). We found phosphorylated tau (p-tau)-positive and α-synuclein-negative TuSAs in 10 of 60 patients with LBD and 3 of 85 control… CONTINUE READING
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Clinical neuropathological correlates of Lewy body disease

  • N Hishikawa, HashizumeY, M Yoshida, G Sobue
  • Acta Neuropathol
  • 2003
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