Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

@article{Moltke2016TuftcellderivedIR,
  title={Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit},
  author={Jakob von Moltke and Ming Ji and H J Liang and Richard M Locksley},
  journal={Nature},
  year={2016},
  volume={529},
  pages={221-225}
}
Parasitic helminths and allergens induce a type 2 immune response leading to profound changes in tissue physiology, including hyperplasia of mucus-secreting goblet cells and smooth muscle hypercontractility. This response, known as ‘weep and sweep’, requires interleukin (IL)-13 production by tissue-resident group 2 innate lymphoid cells (ILC2s) and recruited type 2 helper T cells (TH2 cells). Experiments in mice and humans have demonstrated requirements for the epithelial cytokines IL-33… CONTINUE READING
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