Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia.

@article{Arya1996TucaresolIO,
  title={Tucaresol increases oxygen affinity and reduces haemolysis in subjects with sickle cell anaemia.},
  author={Roopen Arya and Paul Edward Rolan and Richard S Wootton and John Posner and Alistair Bellingham},
  journal={British journal of haematology},
  year={1996},
  volume={93 4},
  pages={
          817-21
        }
}
The primary pathophysiological event in sickling is the intracellular polymerization of deoxygenated haemoglobin S. Tucaresol (589C80;4[2-formyl-3-hydroxyphenoxymethyl] benzoic acid), a substituted benzaldehyde, was designed to interact with haemoglobin to increase oxygen affinity and has been shown to inhibit sickling in vitro. We administered tucaresol to sickle cell patients in the steady state to examine the anti-sickling effect in vivo. Oral doses of tucaresol or placebo were given to nine… CONTINUE READING
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