Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.

@article{Chou2007TubulozoleinducedGC,
  title={Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation.},
  author={Yean-Hwei Chou and Y H Ho and Chi-Chen Wu and Chiah-Yang Chai and Soul-Chin Chen and Chia-Hwa Lee and Pei-Shan Tsai and Chih-hsiung Wu},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2007},
  volume={45 8},
  pages={1356-67}
}
Our studies demonstrated that human colon cancer cells (COLO 205), with higher expression level of check point kinase 1 (Chk1), were more sensitive to microtubule damage agent Tubulozole (TUBU) induced G2/M phase arrest than normal human colon epithelial (CRL) cells. TUBU (10 microM, for 3h) treatment resulted in rapid and sustained phosphorylation of Cdc25C (Ser-216) leading to increased 14-3-3beta binding. This resulted in increased nuclear translocation. In addition, TUBU induced… CONTINUE READING

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