Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.

@article{Dimke2015TubulovascularCB,
  title={Tubulovascular cross-talk by vascular endothelial growth factor a maintains peritubular microvasculature in kidney.},
  author={Henrik Dimke and Matthew A Sparks and Benjamin R. Thomson and Sebastian Frische and Thomas M. Coffman and Susan E Quaggin},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2015},
  volume={26 5},
  pages={
          1027-38
        }
}
Vascular endothelial growth factor A (VEGFA) production by podocytes is critical for glomerular endothelial health. VEGFA is also expressed in tubular epithelial cells in kidney; however, its physiologic role in the tubule has not been established. Using targeted transgenic mouse models, we found that Vegfa is expressed by specific epithelial cells along the nephron, whereas expression of its receptor (Kdr/Vegfr2) is largely restricted to adjacent peritubular capillaries. Embryonic deletion of… CONTINUE READING
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