Tubulointerstitial nephritis antigen: an extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development.

@article{Kanwar1999TubulointerstitialNA,
  title={Tubulointerstitial nephritis antigen: an extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development.},
  author={Yashpal S. Kanwar and Anil Kumar and Qiwei Yang and Yufeng Tian and Jun Wada and Naoki Kashihara and Elisabeth I Wallner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 20},
  pages={11323-8}
}
Tubulointerstitial nephritis antigen (TIN-ag) is an extracellular matrix protein and is expressed in the renal tubular basement membranes. Its role in metanephric development was investigated. TIN-ag cDNA, isolated from the newborn mouse library, had an ORF of 1,425 nucleotides, a putative signal sequence, and an ATP/GTP-binding site. The translated sequence had approximately 80% identity with rabbit TIN-ag. Among various tissues, TIN-ag mRNA was primarily expressed in the newborn kidney. In… CONTINUE READING
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