Tubulogenesis in the developing mammalian kidney.

@article{Dressler2002TubulogenesisIT,
  title={Tubulogenesis in the developing mammalian kidney.},
  author={Gregory R Dressler},
  journal={Trends in cell biology},
  year={2002},
  volume={12 8},
  pages={390-5}
}
How do fibroblasts spontaneously organize into a polarized epithelial tube? This question has fascinated scientists studying the mammalian kidney for more than 40 years. The formation of epithelial tubules in the developing mammalian kidney involves both the aggregation of mesenchymal cells and their conversion into polarized epithelium, as well as the growth and branching morphogenesis of existing epithelium. The interactions among mesenchyme, epithelia and, more recently, the stroma, have… CONTINUE READING

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