Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone

@article{Marcos2009TubulinTI,
  title={Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone},
  author={S{\'e}verine Marcos and Julie Moreau and St{\'e}phanie Backer and Didier Job and Annie Andrieux and Evelyne Bloch-Gallego},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={84 - 91}
}
BACKGROUND During development, neuronal growth cones integrate diffusible and contact guidance cues that are conveyed to both actin and microtubule (MT) cytoskeletons and ensure axon outgrowth and pathfinding. Although several post-translational modifications of tubulin have been identified and despite their strong conservation among species, their physiological roles during development, especially in the nervous sytem, are still poorly understood. METHODOLOGY/FINDINGS Here, we have dissected… CONTINUE READING

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