Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins

@article{Kubo2010TubulinPR,
  title={Tubulin Polyglutamylation Regulates Axonemal Motility by Modulating Activities of Inner-Arm Dyneins},
  author={Tomohiro Kubo and Haru-aki Yanagisawa and Toshiki Yagi and Masafumi Hirono and Ritsu Kamiya},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={441-445}
}
Tubulin polyglutamylation is a modification that adds multiple glutamates to the gamma-carboxyl group of a glutamate residue in the C-terminal tails of alpha- and beta-tubulin [1, 2]. This modification has been implicated in the regulation of axonal transport and ciliary motility. However, its molecular function in cilia remains unknown. Here, using a novel Chlamydomonas reinhardtii mutant (tpg1) that lacks a homolog of human TTLL9, a glutamic acid ligase enzyme [3], we found that the lack of a… CONTINUE READING

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