Tubulin Is a Neuronal Target of Autoantibodies in Sydenham’s Chorea1

@article{Kirvan2007TubulinIA,
  title={Tubulin Is a Neuronal Target of Autoantibodies in Sydenham’s Chorea1},
  author={C. Kirvan and C. Cox and S. Swedo and M. Cunningham},
  journal={The Journal of Immunology},
  year={2007},
  volume={178},
  pages={7412 - 7421}
}
Sydenham’s chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbs 24.3.1, 31.1.1, and 37.2.1 derived from chorea and selected for cross-reactivity with group A streptococci and brain Ags. Our novel findings reveal that Sydenham’s chorea mAbs target a 55-kDa brain protein with an N-terminal amino acid sequence of MREIVHLQ corresponding to β-tubulin. Chorea mAb… Expand
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