Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity

@article{Suryavanshi2010TubulinGR,
  title={Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm Activity},
  author={Swati Suryavanshi and Bernard Edd{\'e} and Laura A. Fox and Stella Guerrero and Robert J Hard and Todd Hennessey and Amrita Kabi and David Malison and David G. Pennock and Winfield S Sale and Dorota Wloga and Jacek Gaertig},
  journal={Current Biology},
  year={2010},
  volume={20},
  pages={435-440}
}
How microtubule-associated motor proteins are regulated is not well understood. A potential mechanism for spatial regulation of motor proteins is provided by posttranslational modifications of tubulin subunits that form patterns on microtubules. Glutamylation is a conserved tubulin modification [1] that is enriched in axonemes. The enzymes responsible for this posttranslational modification, glutamic acid ligases (E-ligases), belong to a family of proteins with a tubulin tyrosine ligase (TTL… CONTINUE READING