Tubularized urethral replacement with unseeded matrices: what is the maximum distance for normal tissue regeneration?

@article{Dorin2008TubularizedUR,
  title={Tubularized urethral replacement with unseeded matrices: what is the maximum distance for normal tissue regeneration?},
  author={Ryan Paul Dorin and Hans G. Pohl and Roger E. De Filippo and James J Yoo and Anthony J Atala},
  journal={World Journal of Urology},
  year={2008},
  volume={26},
  pages={323-326}
}
Complete urethral replacement using unseeded matrices has been proposed as a possible therapy in cases of congenital or acquired anomalies producing significant defects. Tissue regeneration involves fibrin deposition, re-epithelialization, and remodeling that are limited by the size of the defect. Scar formation occurs because of an inability of native cells to regenerate over the defect before fibrosis takes place. We investigated the maximum potential distance of normal native tissue… CONTINUE READING