Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2.

  title={Tubular proteinuria in mice and humans lacking the intrinsic lysosomal protein SCARB2/Limp-2.},
  author={Michael J. Desmond and D Lee and Scott A. Fraser and Marina Katerelos and Kurt Gleich and Paul Martinello and Y. Q. Li and M. C. Thomas and Roberto Michelucci and Andrew J. Cole and Paul Saftig and Michael Schwake and David I. Stapleton and Samuel F. Berkovic and David A. Power},
  journal={American journal of physiology. Renal physiology},
  volume={300 6},
  • M. J. Desmond, D. Lee, D. Power
  • Published 1 June 2011
  • Biology, Medicine, Chemistry
  • American journal of physiology. Renal physiology
Deficiency of the intrinsic lysosomal protein human scavenger receptor class B, member 2 (SCARB2; Limp-2 in mice) causes collapsing focal and segmental glomerular sclerosis (FSGS) and myoclonic epilepsy in humans, but patients with no apparent kidney damage have recently been described. We now demonstrate that these patients can develop tubular proteinuria. To determine the mechanism, mice deficient in Limp-2, the murine homolog of SCARB2, were studied. Most low-molecular-weight proteins… 

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