Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila

@inproceedings{Fabrowski2013TubularED,
  title={Tubular endocytosis drives remodelling of the apical surface during epithelial morphogenesis in Drosophila},
  author={Piotr Fabrowski and Aleksandar S. Necakov and Simone Mumbauer and Eva Loeser and Alessandra Reversi and Sebastian Streichan and John A. G. Briggs and Stefano De Renzis},
  booktitle={Nature communications},
  year={2013}
}
During morphogenesis, remodelling of cell shape requires the expansion or contraction of plasma membrane domains. Here we identify a mechanism underlying the restructuring of the apical surface during epithelial morphogenesis in Drosophila. We show that the retraction of villous protrusions and subsequent apical plasma membrane flattening is an endocytosis-driven morphogenetic process. Quantitation of endogenously tagged GFP::Rab5 dynamics reveals a massive increase in apical endocytosis that… CONTINUE READING
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