Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH.

  title={Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH.},
  author={Aviad Haramati and Franklyn G. Knox},
  journal={The American journal of physiology},
  volume={244 2},
  • A. Haramati, F. Knox
  • Published 1 February 1983
  • Chemistry, Medicine
  • The American journal of physiology
The present study tested the hypothesis that nicotinamide and/or parathyroid hormone (PTH) would reverse the resistance of phosphate-deprived rats to the phosphaturic effects of phosphate infusions by reducing the tubular capacity for phosphate transport. The response to progressively increasing rates of phosphate infusion (1, 2, and 3 mumol/min) was evaluated in thyroparathyroidectomized (TPTX) rats fed low phosphate diet (0.07%) for 4 days and treated with either vehicle or nicotinamide 2 h… Expand
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Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats.
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Dissociation of tubular sites of action of saline, PTH and DbCAMP on renal phosphate reabsorption.
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Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rat.
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Factors involved in the altered phosphate reabsorption during phosphate loading in thyroparathyroidectomized rats.
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Micropuncture studies performed on dogs that received a highly purified preparation of parathyroid hormone, dibutyryl cyclic 3',5'-adenosine monophosphate (cyclic AMP), 5'-AMP, and saline support the thesis that renal effects of PTH are mediated via stimulation of renal cortical adenyl cyclase. Expand