Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH.

@article{Haramati1983TubularCO,
  title={Tubular capacity of phosphate transport in phosphate-deprived rats: effects of nicotinamide and PTH.},
  author={Aviad Haramati and Franklyn G. Knox},
  journal={The American journal of physiology},
  year={1983},
  volume={244 2},
  pages={
          F178-84
        }
}
  • A. Haramati, F. Knox
  • Published 1 February 1983
  • Chemistry, Medicine
  • The American journal of physiology
The present study tested the hypothesis that nicotinamide and/or parathyroid hormone (PTH) would reverse the resistance of phosphate-deprived rats to the phosphaturic effects of phosphate infusions by reducing the tubular capacity for phosphate transport. The response to progressively increasing rates of phosphate infusion (1, 2, and 3 mumol/min) was evaluated in thyroparathyroidectomized (TPTX) rats fed low phosphate diet (0.07%) for 4 days and treated with either vehicle or nicotinamide 2 h… Expand
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It is concluded that nicotinamide restores the phosphaturic effect of PTH and calcitonin in rats fed a low phosphate diet by acting at a cellular step subsequent to cAMP generation to inhibit tubular reabsorption of phosphate. Expand
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The results indicate that the renal phosphaturic responses to PTH and cyclic AMP are impaired during dietary phosphorus deprivation, which would contribute to phosphorus conservation and to the replenishment of inorganic phosphate stores after phosphorus depletion. Expand
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