Tubular aggregates in skeletal muscle: just a special type of protein aggregates?

  title={Tubular aggregates in skeletal muscle: just a special type of protein aggregates?},
  author={Stefano Schiaffino},
  journal={Neuromuscular disorders : NMD},
  volume={22 3},
Tubular aggregates are inclusions, usually found in type II muscle fibers and in males, consisting of regular arrays of tubules derived from the sarcoplasmic reticulum. Tubular aggregates are associated with a wide variety of muscle disorders, including poorly defined "tubular aggregate myopathies" characterized by weakness and/or myalgia and/or cramps, and are also present in different mouse models, including normal aging muscles. The mechanism(s) responsible for inducing the formation of… CONTINUE READING


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