Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study

  title={Tuberous sclerosis in a 20-week gestation fetus: immunohistochemical study},
  author={Sung-Hye Park and Samuel H. Pepkowitz and Christopher A Kerfoot and Michael De Rosa and Vadims Poukens and Ralf Wienecke and Jeffrey E Declue and H V Vinters},
  journal={Acta Neuropathologica},
We report an autopsy case of tuberous sclerosis complex (TSC) in a 20-week gestational age female fetus. The brain showed lesions suggestive of early cortical tubers and subependymal hamartomatous nodules. The large cells within these nodular clusters were variably immunoreactive for glial fibrillary acidic protein (GFAP) and vimentin and negative for synaptophysin and neurofilament. Subependymal radial glia expressed both vimentin and GFAP, but subpial radial glia either did not express these… CONTINUE READING


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