Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

@article{Tee2003TuberousSC,
  title={Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb},
  author={Andrew R. Tee and Brendan D. Manning and Philippe P Roux and Lewis C. Cantley and John Blenis},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1259-1268}
}

Figures from this paper

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TLDR
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TLDR
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TLDR
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Hamartin and tuberin function together to inhibit mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1), which strongly implicate the tuberin-hamartin tumor suppressor complex as an inhibitor of mTOR.
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