Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.

@article{Jung2016TuberostemonineNA,
  title={Tuberostemonine N, an active compound isolated from Stemona tuberosa, suppresses cigarette smoke-induced sub-acute lung inflammation in mice.},
  author={Kyung-Hwa Jung and Yun‐Seo Kil and Jae-Ri Jung and Soojin Park and Dasom Shin and Kyeseok Lee and E. Seo and H. Bae},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2016},
  volume={23 1},
  pages={
          79-86
        }
}
OBJECTIVE Our previous study demonstrated that a Stemona tuberosa extract had significant effects on cigarette smoking (CS)-induced lung inflammation in mice. The present study evaluated the potential of tuberostemonine N (T.N) to prevent airway inflammation and suppress airway responses in a CS-induced in vivo COPD model. METHODS T.N was isolated from the root of ST and analyzed using 1D and 2D NMR. The purity of T.N was accessed using HPLC-ELSD analysis. C57BL/6 mice in this study were… Expand
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