Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition.

@article{Barnes2010TuberinRE,
  title={Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition.},
  author={Elizabeth A. Barnes and Heidi L. Kenerson and Xiuyun Jiang and Raymond Yeung},
  journal={The American journal of pathology},
  year={2010},
  volume={177 4},
  pages={1765-78}
}
The tuberous sclerosis complex 2 (TSC2) gene encodes the protein tuberin, which functions as a key negative regulator of both mammalian target of rapamycin (mTOR) C1-dependent cell growth and proliferation. Loss-of-function mutations of TSC2 result in mTORC1 hyperactivity and predispose individuals to both tuberous sclerosis and lymphangioleiomyomatosis. These overlapping diseases have in common the abnormal proliferation of smooth muscle-like cells. Although the origin of these cells is… CONTINUE READING