Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.

@article{Rosner2004TuberinBP,
  title={Tuberin binds p27 and negatively regulates its interaction with the SCF component Skp2.},
  author={Margit Rosner and Markus Hengstschlaeger},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 47},
  pages={48707-15}
}
TSC1 (tuberous sclerosis complex 1) encoding hamartin and TSC2 encoding tuberin are tumor suppressor genes responsible for the autosomal dominantly inherited disease tuberous sclerosis. These genes have been demonstrated to negatively regulate cell cycle progression, the activity of cdk2, and the degradation of the cyclin-dependent kinase inhibitor p27. To date, the underlying molecular mechanism remains elusive. Here, we show that tuberin binds to p27. Whereas tuberin also binds p27 in TSC1… CONTINUE READING

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