Tuberculosis subunit vaccine development: on the role of interferon-gamma.

  title={Tuberculosis subunit vaccine development: on the role of interferon-gamma.},
  author={Else Marie Agger and Peter Hvilsh\oj Andersen},
  volume={19 17-19},
Tuberculosis (TB) remains a major global health problem and subunit vaccines for the control of the disease are presently under development. This vaccine strategy requires an in vitro correlate of protection for the identification of relevant vaccine candidate antigens and for monitoring the induction of a protective cell-mediated immune response after vaccination. New studies of experimental vaccines in the mouse model of TB support interferon-gamma as a relevant marker for the induction of a… CONTINUE READING


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