Tuberculosis subunit vaccine design: the conflict of antigenicity and immunogenicity.

@article{Sable2007TuberculosisSV,
  title={Tuberculosis subunit vaccine design: the conflict of antigenicity and immunogenicity.},
  author={Suraj B. Sable and Mamta Kalra and Indu Verma and Gopal Krishan Khuller},
  journal={Clinical immunology},
  year={2007},
  volume={122 3},
  pages={239-51}
}
The attempts to find an effective antituberculous subunit vaccine are based on the assumption that it must drive a Th1 response. In the absence of effective correlates of protection, a vast array of mycobacterial components are being evaluated worldwide either on the basis of their ability to be recognized by T lymphocytes in in vitro assays during early stage of animal or human infection (antigenicity) or their capacity to induce T cell response following immunization in animal models… CONTINUE READING