Tuberculosis-spoligo-rifampin-isoniazid typing: an all-in-one assay technique for surveillance and control of multidrug-resistant tuberculosis on Luminex devices.

@article{Gomgnimbou2013Tuberculosisspoligorifampinison,
  title={Tuberculosis-spoligo-rifampin-isoniazid typing: an all-in-one assay technique for surveillance and control of multidrug-resistant tuberculosis on Luminex devices.},
  author={Michel Kir{\'e}opori Gomgnimbou and Iv{\'a}n Hern{\'a}ndez-Neuta and Stefan Panaiotov and Elizabeta Bachiyska and Juan Carlos Lezama Palomino and Anandi Martin and Patricia del Portillo and Guislaine Refregier and Christophe Sola},
  journal={Journal of clinical microbiology},
  year={2013},
  volume={51 11},
  pages={
          3527-34
        }
}
As a follow-up of the "spoligoriftyping" development, we present here an extension of this technique which includes the detection of isoniazid resistance-associated mutations in a new 59-plex assay, i.e., tuberculosis-spoligo-rifampin-isoniazid typing (TB-SPRINT), running on microbead-based multiplexed systems. This assay improves the synergy between clinical microbiology and epidemiology by providing (i) mutation-based prediction of drug resistance profiles for patient treatment and (ii… CONTINUE READING

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