Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis

@article{Lastrucci2015TuberculosisIA,
  title={Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16+ monocyte population via the IL-10/STAT3 axis},
  author={Claire Lastrucci and Alan B{\'e}nard and Luciana Balboa and Karine Pingris and Shanti Souriant and Renaud Poincloux and Talal Al Saati and Voahangy Rasolofo and Pablo Gonz{\'a}lez-Montaner and Sandra Inwentarz and Eduardo Jose Mora{\~n}a and Ivanela Kondova and Frank A. W. Verreck and Mar{\'i}a Del Carmen Sasiain and Olivier Neyrolles and Isabelle Maridonneau-Parini and Geanncarlo Lugo-Villarino and C{\'e}line Cougoule},
  journal={Cell Research},
  year={2015},
  volume={25},
  pages={1333-1351}
}
The human CD14+ monocyte compartment is composed by two subsets based on CD16 expression. We previously reported that this compartment is perturbed in tuberculosis (TB) patients, as reflected by the expansion of CD16+ monocytes along with disease severity. Whether this unbalance is beneficial or detrimental to host defense remains to be elucidated. Here in the context of active TB, we demonstrate that human monocytes are predisposed to differentiate towards an anti-inflammatory (M2-like… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 21 times over the past 90 days. VIEW TWEETS
23 Citations
77 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 77 references

Ly 6 Chigh monocytes become alternatively activated macrophages in schisto - some granulomas with help from CD 4 + cells

  • NM Girgis, UM Gundra, LN Ward
  • PLoS Pathog
  • 2014

Similar Papers

Loading similar papers…