Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells.

@article{Yuan2009TuberculosisinducedVI,
  title={Tuberculosis-induced variant IL-4 mRNA encodes a cytokine functioning as growth factor for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T cells.},
  author={Zhuqing Yuan and Richard C. Wang and Yuyang Lee and Crystal Y. Chen and XingBing Yu and Zhongdao Wu and Dan ” Huang and Ling Shen and Z Chen},
  journal={Journal of immunology},
  year={2009},
  volume={182 2},
  pages={811-9}
}
The possibility that mycobacterial infections induce variant cytokine mRNA encoding a functionally distinct protein for immune regulation has not been addressed. In this study, we reported that Mycobacterium tuberculosis and bacillus Calmette-Guérin infections of macaques induced expression of variant IL-4 (VIL-4) mRNA encoding a protein comprised of N-terminal 97 aa identical with IL-4, and unique C-terminal 96 aa including a signaling-related proline-rich motif. While VIL-4 could be stably… CONTINUE READING